|
ИСТИНА |
Войти в систему Регистрация |
Интеллектуальная Система Тематического Исследования НАукометрических данных |
||
Difference in pallidal single unit activity in cervical dystonia with jerky and sinusoidal head tremorтезисы доклада
- Авторы: Sedov A., Usova S., Semenova U., Gamaleya A., Tomskiy A., Beylergil S.B., Jinnah H.A., Shaikh A.
- Сборник: 2019 Neuroscience Meeting Planner
- Серия: Online
- Тезисы
- Год издания: 2019
- Издательство: Society for Neuroscience
- Местоположение издательства: United States
- Первая страница: Program No. 580.09
- Последняя страница: Program No. 580.09
- Аннотация: Two common movement disorders, dystonia and tremor, frequently overlap. Their biological relationships remain unclear. One hypothesis is that tremor and dystonia are due to the same fundamental biological process. A second hypothesis is that tremor and dystonia are due to distinct biological processes which frequently co-occur. Here we test these hypotheses by measuring the physiological activity of the globus pallidus in the most common form of dystonia, cervical dystonia, which frequently combines with tremor of the head. We compared three groups of patients, those with no tremor at all (pure dystonia), those with jerky head oscillations (dystonic tremor), and those with sinusoidal tremor. We used microelectrode recording from 13 CD subjects undergoing deep brain stimulation (DBS) surgery under local anesthesia. We analyzed the spontaneous activity of 727 pallidal neurons (398 GPi and 329 GPe). Clustering of spike-train recordings allowed classification of pallidal activity according to burst, pause, and tonic neurons - the types of neurons expected in dystonia patients. We found the differences in cells distribution between analyzed groups of patients. Burst GPi neurons were more common in pure dystonia or dystonic tremor groups compared to the sinusoidal tremor group. Pause GPi and GPe neurons were more common in the sinusoidal tremor group compared to the pure dystonia or dystonic tremor groups. In addition to their frequent prevalence, the pause neurons in sinusoidal tremor group had lower firing rate and were more irregular. The number of spikes within the burst were higher and inter-burst intervals were longer in sinusoidal tremor group. Neurons of patients with pure dystonia and dystonic tremor had similar parameters. We also found bihemispheric asymmetry in the dystonic tremor and pure dystonia groups, while such asymmetry was not present in the sinusoidal oscillation group. These results revealing differences in the physiology of pallidal neurons of dystonic and sinusoidal tremor patients, suggest their distinct mechanistic underpinings.
- Добавил в систему: Гамалея Анна Александровна