Neuroprotective effect of hypobaric hypoxic postconditioning is accompanied by dna protection and lipid peroxidation changes in rat hippocampusстатья
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Дата последнего поиска статьи во внешних источниках: 27 ноября 2019 г.
Аннотация:The present study was performed to explore the effect of severe hypobaric hypoxia (180 Torr, 3 h) and
severe hypoxia followed by hypoxic postconditioning (360 Torr, 2 h, 3 episodes) on DNA fragmentation
and dynamics of lipid peroxidation products in rat hippocampus. The severe hypoxia induced intense
DNA fragmentation in the hippocampus. A persistent decrease of thiobarbituric acid reactive substances
in the hippocampus was also detected in response to severe hypoxia while the levels of Schiff bases did
not significantly change. The postconditioning prevented severe hypoxia-induced DNA fragmentation,
returned the levels of thiobarbituric acid reactive substances to the baseline and decreased the levels
of Schiff bases. These findings indicate that the neuroprotective effect of hypoxic postconditioning on
hippocampal neurons detected as suppression of hypoxia-induced DNA fragmentation is accompanied
by the changes in lipid peroxidation processes.