Сравнительная характеристика крыс линий Wistar, Wistar-Kyotо, Sprague Dawley, Long Evans, НП, SHR, BD-IX по поведению, гормональному и антиоксидантному статусустатья
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Аннотация:The rat strains Wistar, Wistar–Kyoto, Sprague Dawley, Long Evans, LT (low CNS
excitability threshold), SHR, BD-IX (“Biocollection of the Pavlov Institute of Physiology”) were
comparatively screened for the indicators of hormonal and antioxidant status as well as behavior.
In male rats, the following characteristics were evaluated: behavioral (locomotor activity, anxiety
level, depressive-like behavior in the Prosolt forced swim test), hormonal (corticosterone,
dehydroepiandrosterone—DHEA, thyroid-stimulating hormone—TSH, thyroxine and testosterone
levels) and blood antioxidative activity. Considering our data on physiological phenotyping the above
rat strains, physiological maps were created for each strain and a specific descriptive biocollection
format was elaborated to represent relevant information as a publicly available online resource
(http://hst5.infran.ru/biocollection/) which can be helpful in choosing an experimental object and
instrumental in analyzing data obtained on certain rat strains.