Detection of the Causative Agent of Tularemia by Surface Plasmon Resonanceстатья

Информация о цитировании статьи получена из Scopus, Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 октября 2019 г.

Работа с статьей


[1] Detection of the causative agent of tularemia by surface plasmon resonance / A. A. Isakovaa, I. V. Zharnikova, T. V. Zharnikova, A. V. Indenbom // Protection of Metals and Physical Chemistry of Surfaces. — 2019. — Vol. 55, no. 2. — P. 407–411. A method for detection of causative agent of tularemia in aqueous solutions by surface plasmon resonance spectrometry was proposed. The kinetics of immobilization of antibodies to Francisella tularensis on the surface of gold-plated glass chips was studied. Based on a quantitative analysis of the results, it was concluded that the antibody molecules were predominantly laterally oriented on the surface. This conclusion was confirmed by analysis of sensorgrams of the subsequent antigen–antibody interaction. It is shown that the proposed method can reliably determine the presence of the causative agent of tularemia in aqueous solutions with a sensitivity of 100 cell/mL for several minutes. Various options for improving this method for detection of the tularemia causative agent to increase its sensitivity have been proposed. [ DOI ]

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