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The polymorphism of regulatory region of NOS3 gene (rs2070744, genotype CC) protect patients from chronic migraineстатья
- Авторы: Klimov E., Kondratieva N., Skorobogatykh K., Azimova J., Sergeev A., Kokaeva Z., Naumova E., Rachin A., Tabeeva G.
- Журнал: British journal of medicine and medical research
- Том: 16
- Номер: 10
- Год издания: 2016
- Издательство: Sciencedomain International
- Местоположение издательства: Gurgaon, India
- Первая страница: 1
- Последняя страница: 7
- DOI: 10.9734/BJMMR/2016/26738
- Аннотация: Aims: There is evidence that endothelial nitric oxide synthase has a role in migraine pathophysiology. In our research, the role of SNP rs2070744 (c.-813C>T) in promoter region of NOS3 gene in the episodic and chronic forms of migraine is considered. Place and Duration of Study: University Headache Clinic between June 2012 and November 2014 and Department of Genetics, Faculty of Biology of Lomonosov Moscow State University between October 2013 and March 2016. Methodology: The study included 138 patients with migraine (44 with chronic and 96 with episodic migraine). The control group included 348 unexamined subjects. Genotypes were determined using real-time PCR with allelic discrimination test. Statistical processing was performed using Fisher test and Pearson's chi-squared test. Results: Our study evaluated the link of CC genotype of rs2070744 with migraine (Fisher’s p=0.026) and episodic migraine (Fisher’s p=0.022). Conclusion: Genotype CC of SNP rs2070744 in the regulatory region of NOS3 gene is more specific for episodic migraine and may prevents the chronification of migraine.
- Добавил в систему: Климов Евгений Александрович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Klimov16102016BJMMR26738.pdf | 239,8 КБ | 12 июля 2016 [KlimovEA] |