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Various Schemes of Neurotransplantation were Found for Suppression of Audiogenic Seizures in Different Strains of Ratsстатья
Дата последнего поиска статьи во внешних источниках: 28 февраля 2020 г.
- Авторы: Ermakova I., Kuznetsova G., Loseva E., loffe M.
- Журнал: Epilepsia
- Том: 38
- Номер: S3
- Год издания: 1997
- Издательство: Blackwell Publishing Inc.
- Местоположение издательства: United Kingdom
- Первая страница: 174
- Последняя страница: 174
- DOI: 10.1111/j.1528-1157.1997.tb02952.x
- Аннотация: Various Schemes of Neurotransplantation were Found for Suppression of Audiogenic Seizures in Different Strains of Rats. IV Ennakova, GD Kuznetsova, EV Loseva, ME loffe, (Inst. of Higher Nervous Activity and Neurophysiology, Russia) Transplantation of solid grafts, taken from newborn brain, was perfonned in three strains of rats with audiogenic seizures (AS): Wistar rats, which showed a middle level of epileptic sensitivity; Krushinski-Molodkina rats (KM) with strong AS; and WAGiRij rats with some AS and spike-wave discharges, characteristic for generalised absence epilepsy. Combined transplantation of cerebellum+striatuin (cer+str) tissue into parietal cortex led to the suppression of AS in Wistar rats (in 83%). to the decrease of seizure intensity in KM rats (in 50%) and to the reinforcement of AS in WAGiRij (in 75%). AS disappeared in KM (in 71%) after combined transplantation of cerfstr into inferior colliculus and parietal cortex simultaneously. Suppression of AS in WAG/Rij (in 62%) was obtained after transplantation of substantia nigra tissue into the parietal cortex. It was concluded that for each fonn ofepilepsy it was necessary an adequate scheme oftransplantation, which promoted the stable suppressive graft effect. This effect, possibly, was mediated by restoration of the disturbed balance of certain neurotransmitters, which play a key role in the genesis ofvarious fonns of epilepsy.
- Добавил в систему: Иоффе Марат Евсеевич