Biosynthesis, biodegradation, and application of poly(3-hydroxybutyrate) and its copolymers - natural polyesters produced by diazotrophic bacteriaстатья

Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.

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[1] Biosynthesis, biodegradation, and application of poly(3-hydroxybutyrate) and its copolymers - natural polyesters produced by diazotrophic bacteria / A. P. Bonartsev, V. L. Myshkina, D. A. Nikolaeva et al. // Communicating Current Research and Educational Topics and Trends in Applied Microbiology. — Vol. 1. — Formatex Spain, 2007. — P. 295–307. Polyhydroxyalkanoates (PHAs) are bacterial polymers that are formed as naturally occurring storage polyesters by a wide range of microorganisms. Biodegradable and biocompatible poly(3-hydroxybutyrate) (PHB) and its copolymers with 3-hydroxyvalerate (PHBV) are the best known representatives of PHA family. For more than 20 years biosynthesis, biodegradation and applications of PHB and its copolymers have been studied in the Bach Institute of Biochemistry RAS. An effective technology for production of PHB and PHBV of different molecular weight (from 200 to 1500 kDa) by diazotrophic bacteria of Azotobacter and Rhizobium genus has been developed. In order to clarify mechanism of PHB biodegradation degradation of PHB at different conditions in vitro and in vivo have been studied. A number of medical devices on basis of PHB: surgical meshes, screws and plates for bone fixation, periodontal membranes, and wound dressing are developed. High biocompatibility of PHB films and medical devices implanted in animal tissues has been demonstrated. Nowadays, development of systems of sustained drug delivery on the base of PHAs microspheres and microcapsules as a new and promising trend in the modern pharmacology is intensively in progress.

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