Effects of Antioxidants on the Viability of the Human Neuroblastoma SH-SY5Y Cell Culture under the Conditions of Heavy-Metal Toxicity

Авторы: Kulikova O.I., Fedorova T.N., Lopachev A.V., Orlova V.S., Grachev V.A.
Журнал: Biology and medicine
Том: 8
Номер: 4
Год издания: 2016
Издательство: Biology and Medicine Journal
Местоположение издательства: Aligarh, India, India
DOI: 10.4172/0974-8369.1000305
Аннотация: Protective action of antioxidants (mexidol, carnosine, N-acetyl cysteine) and the metal chelator Ca, Na2-EDTA was studied in the culture of human neuroblastoma SH-SY5Y cells after the addition of salts of heavy metals—lead, cadmium, cobalt, and molybdenum—to the culture medium. Cells were incubated with heavy metals and protectors for 24 h, and cell viability and cell death were evaluated. All the metals lowered cell viability in a concentration-related manner. Different protective agents were studied based on this model. The most pronounced capability of increasing the cell viability in conditions of heavy-metal toxicity was demonstrated by N-acetyl cysteine (the protective effect was demonstrated at the concentrations 0.5-1.0 mM and higher). Protective potential of carnosine was somewhat lower and that of mexidol was minimal.
Добавил в систему: Лопачев Александр Васильевич

	ИСТИНА	Войти в систему Регистрация
	Интеллектуальная Система Тематического Исследования НАукометрических данных
	Главная Поиск Статистика О проекте Помощь

ИСТИНА