Gold Nanoparticles Disturb Nuclear Chromatin Decondensation in Mouse Sperm in vitroстатья
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Дата последнего поиска статьи во внешних источниках: 4 февраля 2014 г.
Аннотация:The effect of gold nanoparticles on mouse epididymal sperm has been studied using the model system of nuclear chromatin decondensation in vitro. It is shown that the treatment of gametes, preliminary membrane-freed by sodium dodecyl sulfate, in the mediums containing gold nanoparticles (with diameter ~2.5 nm) in concentrations 1.0 x 1015 or 0.5 x 1015 particles/ml and following incubation in dithiothreitol solution (DTT) resulted in failure of chromatin decondensation process and nucleus structure. We conclude that gold nanoparticles possess spermatotoxicity. The mechanism of cytotoxic effect of gold nanoparticles may be related with their interaction with molecules of double helix DNA. The model system studied in this
research is applicable for further investigations of cytotoxic effects of nanoparticles of different origin and made of different metals.