Nanodiamonds-film as a modifier for improving heart valve biological prostheses materials

Chernysheva, M.G.; Chaschin, I.S.; Sinolits, A.V.; Vasil'ev, V.G.; Popov, A.G.; Badun, G.A.; Bakuleva, N.P.

Авторы: Chernysheva M.G., Chaschin I.S., Sinolits A.V., Vasil'ev V.G., Popov A.G., Badun G.A., Bakuleva N.P.
Сборник: Book of Abstract 14th International Conference "Advanced Carbon Nanostructures" - ACNS'2019, July 1-5, 2019 St. Petersburg, Russia
Тезисы
Год издания: 2019
Место издания: Ioffe Physico-Technical Institute St. Petersburg
Первая страница: 308
Последняя страница: 308
Аннотация: Xenogenic biological prostheses of the heart valves based on bovine pericardium are intensively used in the world of cardiac surgery practice because it is sufficiently strong and elastic material that is rich in collagen connective tissue. The valve also should have a high biocompatibility to eliminate toxic effects on the human body. In present study we applied nanodiamond coverage of bovine pericardium to provide pericardium tissue additional strength. To prepare nanodiamond film on the surface of bovine pericardium matrix was stirred in the aqueous suspension of nanodiamonds. The thickness of the film was determined with the help of tritium labeled nanodiamonds that were obtained using tritium thermal activation method [1]. The obtained material was characterized by scanning electron microscopy. To characterize coated matrix mechanical properties, the collagen samples were initially cut into rectangular pieces with lateral sizes of approximately 7×0.5 cm2 were coated with NDs and stress–strain curves were recorded with a universal testing machine 5 kN load cell LLOYD Instruments LR5R. Modification of the matrix with nanodiamonds results in the increase of both final values of Young modules and tensile strength. Moreover, it was found, that premodification of nanodiamonds with chitosan results in further increase of both values. The preparation of matrix and observed effects will be discussed in the presentation. This work was supported by Russian Foundation for Basic Research (grants № 17-03-00985, 17-03-00362, 18-33-20147). Electron microscopy characterization was performed in the Department of Structural Studies of Zelinsky Institute of Organic Chemistry, Moscow.
Добавил в систему: Бадун Геннадий Александрович

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