[DYNAMICS OF CYTOKINE CONCENTRATION IN THE BLOOD OF RATS WITH VARIOUS BEHAVIORAL CHARACTERISTICS AFTER ACUTE EMOTIONAL STRESS]статья

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[1] [dynamics of cytokine concentration in the blood of rats with various behavioral characteristics after acute emotional stress] / S. S. Pertsov, L. S. Kalinichenko, E. V. Koplik et al. // Rossiĭskii fiziologicheskiĭ zhurnal imeni I.M. Sechenova / Rossiĭskaia akademiia nauk. — 2015. — Vol. 101, no. 9. — P. 1032–1041. This work was designed to study a change in cytokine content in the peripheral blood of behaviorally passive and active Wistar rats at various time intervals after acute stress on the model of night-time immobilization. A decrease in the concentration of most pro- and anti-inflammatory cytokines in passive animals was most pronounced immediately and, particularly, 3 days after stress exposure. Variations in the blood cytokine profile after experimental stress were lower in behaviorally active specimens. A statistically significant decrease was observed only in the amount of a proinflammatory cytokine IL-1α and anti-inflammatory cytokines IL-4 and IL-13. As differentiated from passive rats, these changes in active specimens were most pronounced 1 day after negative emotiogenic exposure. Our results illustrate a specific involvement of immunoactive substances in the systemic regulation of physiological functions and development of individual resistance to the negative consequences of stress.

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