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Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in miceстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 июля 2019 г.
- Авторы: Piliponsky AM, Shubin NJ, Lahiri AK, Truong P., Clauson M., Niino K., Tsuha AL, Nedospasov SA, Karasuyama H., Reber LL, Tsai M., Mukai K., Galli SJ
- Журнал: Nature Immunology
- Том: 20
- Номер: 2
- Год издания: 2019
- Издательство: Nature Publishing Group
- Местоположение издательства: United Kingdom
- Первая страница: 129
- Последняя страница: 140
- DOI: 10.1038/s41590-018-0288-7
- Аннотация: Basophils are evolutionarily conserved in vertebrates, despite their small numbers and short life span, suggesting that they have beneficial roles in maintaining health. However, these roles are not fully defined. Here we demonstrate that basophildeficient mice exhibit reduced bacterial clearance and increased morbidity and mortality in the cecal ligation and puncture (CLP) model of sepsis. Among the several proinflammatory mediators that we measured, tumor necrosis factor (TNF) was the only cytokine that was significantly reduced in basophil-deficient mice after CLP. In accordance with that observation, we found that mice with genetic ablation of Tnf in basophils exhibited reduced systemic concentrations of TNF during endotoxemia. Moreover, after CLP, mice whose basophils could not produce TNF, exhibited reduced neutrophil and macrophage TNF production and effector functions, reduced bacterial clearance, and increased mortality. Taken together, our results show that basophils can enhance the innate immune response to bacterial infection and help prevent sepsis.
- Добавил в систему: Взорова Нина Владимировна