213Bi production and complexation with new picolinate containing ligandsстатьяИсследовательская статья
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Дата последнего поиска статьи во внешних источниках: 3 сентября 2019 г.
Аннотация:Binding of bismuth cation with two newly synthesized picolinate containing acyclic (L1) and macrocyclic (L2) ligands was studied. Both ligands demonstrate complex formation with Bi3+ under ambient conditions with high complexation constants. Serum stability of the complexes was investigated in serum protein excess of 10- and 100-times. Experiments with no-carrier-added radiobismuth (207Bi and 213Bi) were performed. A one-column 225Ac/213Bi generator system, based on Ac resin (Triskem Inc.), was tested. The overall yield of 213Bi was exceeding 85% with 225Ac breakthrough below 10−4%.