|
ИСТИНА |
Войти в систему Регистрация |
Интеллектуальная Система Тематического Исследования НАукометрических данных |
||
Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patientsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 19 июня 2019 г.
- Авторы: Rostomyan Liliya, Daly Adrian F., Petrossians Patrick, Nachev Emil, Lila Anurag R., Lecoq Anne-Lise, Lecumberri Beatriz, Trivellin Giampaolo, Salvatori Roberto, Moraitis Andreas G., Holdaway Ian, Kranenburg-van Klaveren Dianne J., Zatelli Maria Chiara, Palacios Nuria, Nozieres Cecile, Zacharin Margaret, Ebeling Tapani, Ojaniemi Marja, Rozhinskaya Liudmila, Verrua Elisa, Jaffrain-Rea Marie-Lise, Filipponi Silvia, Gusakova Daria, Pronin Vyacheslav, Bertherat Jerome, Belaya Zhanna, Ilovayskaya Irena, Sahnoun-Fathallah Mona, Sievers Caroline, Stalla Gunter K., Castermans Emilie, Caberg Jean-Hubert, Sorkina Ekaterina, Auriemma Renata Simona, Mittal Sachin, Kareva Maria, Lysy Philippe A., Emy Philippe, De Menis Ernesto, Choong Catherine S., Mantovani Giovanna, Bours Vincent, De Herder Wouter, Brue Thierry, Barlier Anne, Neggers Sebastian J.C.M.M, Zacharieva Sabina, Chanson Philippe, Shah Nalini Samir, Stratakis Constantine A., Naves Luciana A., Beckers Albert
- Журнал: Endocrine-Related Cancer
- Том: 22
- Номер: 5
- Год издания: 2015
- Издательство: Society for Endocrinology
- Местоположение издательства: United Kingdom
- Первая страница: 745
- Последняя страница: 757
- DOI: 10.1530/ERC-15-0320
- Аннотация: Despite being a classical growth disorder, pituitary gigantism has not been studied previously in a standardized way. We performed a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients. We included 208 patients ( 163 males; 78.4%) with growth hormone excess and a current/previous abnormal growth velocity for age or final height > 2 S.D. above country normal means. The median onset of rapid growth was 13 years and occurred significantly earlier in females than in males; pituitary adenomas were diagnosed earlier in females than males (15.8 vs 21.5 years respectively). Adenomas were >= 10 mm (i.e., macroadenomas) in 84%, of which extrasellar extension occurred in 77% and invasion in 54%. GH/IGF1 control was achieved in 39% during long-term follow-up. Final height was greater in younger onset patients, with larger tumors and higher GH levels. Later disease control was associated with a greater difference from mid-parental height (r=0.23, P=0.02). AIP mutations occurred in 29%; microduplication at Xq26.3 - X-linked acrogigantism (X-LAG) - occurred in two familial isolated pituitary adenoma kindreds and in ten sporadic patients. Tumor size was not different in X-LAG, AIP mutated and genetically negative patient groups. AIP-mutated and X-LAG patients were significantly younger at onset and diagnosis, but disease control was worse in genetically negative cases. Pituitary gigantism patients are characterized by male predominance and large tumors that are difficult to control. Treatment delay increases final height and symptom burden. AIP mutations and X-LAG explain many cases, but no genetic etiology is seen in > 50% of cases.
- Добавил в систему: Иловайская Ирэна Адольфовна