Chirally n-substituted indole-2-carbaldehydes. Preparation and use in asymmetric synthesisстатья
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Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.
Авторы:
Golantsov N.E.a,
Karchava A.V.a,
Starikova Z.A.b,
Dolgushin F.M.b ,
Yurovskaya M.A.a
Журнал:
Chemistry of Heterocyclic Compounds
Том:
41
Номер:
10
Год издания:
2005
Издательство:
Kluwer Academic/Plenum Publishers
Местоположение издательства:
United States
Первая страница:
1290
Последняя страница:
1299
DOI:
10.1007/s10593-005-0315-0
Аннотация:
A simple method is proposed for the synthesis of optically active indole-2-carbaldehydes via alkylation of 2-cyanoindole by optically active secondary alcohols and subsequent reduction of the cyano group to an aldehyde. Reaction of the aldehydes obtained with aromatic amines gave imines whose reaction with the Danishefsky diene was studied. The structure of the major diastereomer of (2R′)-1-phenyl-2-[1-((1R′)-1-phenylethyl)indol-2-yl] -1,2,3,4-tetrahydropyridine-4-one and minor diastereomer (2S)-2-[1-((1S)-2- methoxy-1-phenylethyl)indol-2-yl]-1-phenyl-1,2,3,4-tetrahydropyridine-4-one respectively were established by X-ray analysis. ©2005 Springer Science+Business Media, Inc.
Добавил в систему:
Юровская Марина Абрамовна