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Oligonucleotide Microarrays Identified Potential Regulatory Genes Related To Early Outward Arterial Remodeling Induced By Tissue Plasminogen Activatorстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 июля 2019 г.
- Авторы: Plekhanova O., Parfyonova Ye, Beloglazova I., Berk BC, Tkachuk V.
- Журнал: Frontiers in physiology
- Том: 10
- Год издания: 2019
- Издательство: Frontiers Research Foundation
- Местоположение издательства: Switzerland
- Первая страница: 493
- DOI: 10.3389/fphys.2019.00493
- Аннотация: Constrictive vascular remodeling limiting blood flow, as well as compensatoryoutward remodeling, have been observed in many cardiovascular diseases; however, theunderlying mechanisms regulating the remodeling response of the vessels remainunclear. Plasminogen activators (PA) are involved in many of the processes of vascularremodeling. We have shown previously that increased tissue-type PA (tPA) contributesto outward vascular remodeling.To elucidate the mechanisms involved in the induction of outward remodelingwe characterized changes in the expression profiles of 8799 genes in injured rat carotidarteries one and four days after recombinant tPA treatment compared to vehicle.Periadventitial tPA significantly increased lumen size and vessel area, encompassed bythe external elastic lamina, at both one and four days after treatment. Among 41differentially expressed known genes one day after tPA application, 5 genes wereinvolved in gene transcription, 5 genes were related to the regulation of vascular tone(for example, thromboxane A2 receptor (D32080) or nonselective-type endothelinreceptor (S65355)), and 8 genes were identified as participating in vascular innervation(for example, calpain (D14478) or neural cell adhesion molecule L1 (X59149)). Fourdays after injury in tPA-treated arteries, 4 genes, regulating vascular tone, weredifferentially expressed.Thus, tPA promotes outward arterial remodeling after injury, at least in part, byregulating expression of genes in the vessel wall related to function of the nervoussystem and vascular tone.
- Добавил в систему: Плеханова Ольга Сергеевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | tPA-fphys-10-00493.pdf | 517,0 КБ | 4 января 2020 [plekhanova@mail.ru] |