3D printing as the only method to get tailored architecture for bone replacement materials of different kinds

Evdokimov, P.; Putlayev, V.; Garshev, A.; Klimashina, E.; Safronova, T.; Scherbackov, I.; Dubrov, V.; Karalkin, P.

Авторы: Pavel Evdokimov, Valery Putlayev, Alexey Garshev, Elena Klimashina, Tatiana Safronova, Ivan Scherbackov, Vadim Dubrov, Pavel Karalkin
Сборник: yCAM 2019, Conference Abstracts, young Ceramists Additive Manufacturing Forum, April 3-5 2019
Тезисы
Год издания: 2019
Место издания: Université de Mons Mons, Belgium
Первая страница: 36
Последняя страница: 36
Аннотация: The aim of this work is the fabrication of bone replacement materials of different kinds (bioceramics,composites, hydrogels, etc.) as the basis for tissue engineering with a tailored pore space architecture. This materials facilitates efficient and rapid filling of the structure with osteoinductive substances (e.g. platelet mass, bone marrow, spongiosis) and also provides germination of native bone in the implant and vascularization of the newly formed bone tissue. The material matrix framework fulfils the guide and the supporting function at the initial stages of osseointegration of the implant, realising the osteoconductive function of the implant and the corresponding type of osteogenesis. Such matrices can be used alone or be pre-filled with physiologically active substances and/or cell cultures contained, in particular, in the osteoinduced substance taken from the patient (platelet mass, bone marrow, spongiosa); in this aspect of the material application, a personalised approach to bone tissue regeneration is realised. Permeability is among the essential matrix properties, which is determined by a coherent system of macropores with dimensions of 500-1000 μm. One can get such kind of materials with tailored system of macropores only by means of using 3D printing technologies. In this application, we propose the creation of highly porous (> 70% porosity) implant via different methods (SLA, robocasting, FDM, etc.)
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