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PROTEASOMES RAISE THE MICROTUBULE DYNAMICS IN INFLUENZA A (H1N1) VIRUS-INFECTED LLC-MK2 CELLSстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 мая 2016 г.
- Авторы: de Conto Flora, Carlo Chezzi, Alessandra Fazzi, Razin Sergey V., Maria Cristina Arcangeletti, Maria Cristina Medici, Rita Gatti, Adriana Calderaro
- Журнал: Cellular and Molecular Biology Letters
- Том: 20
- Номер: 5
- Год издания: 2015
- Издательство: University of Wroclaw
- Местоположение издательства: Poland
- Первая страница: 840
- Последняя страница: 866
- DOI: 10.1515/cmble-2015-0052
- Аннотация: The dynamics of microtubule networks are known to have an impact on replication of influenza A virus in some cellular models. Here we present evidence suggesting that at late stages of LLC-MK2 cell infection by influenza A (H1N1) virus the ubiquitin-proteasome protein degradation system participates in destabilization of microtubules, and favours virus replication. Chemical inhibition of proteasome activity partially suppresses influenza A virus replication, while stimulation of proteasome activity favours influenza A virus replication. Conversely, in another cellular model, A549 cells, inhibitors and activators of proteasomes have a small effect on influenza A virus replication. These data suggest that influenza A virus might take selective advantage of proteasome functions in order to set up a favourable cytoskeletal “environment” for its replication and spread. Furthermore, the relationship between influenza virus and the host cell is likely to depend on both the cellular model and the virus strain.
- Добавил в систему: Разин Сергей Владимирович