Stereoselective reduction of the active substance of the medicinal preparation dimebon to the corresponding cis - and trans -1,2,3,4,4a ,9b -hexahydro derivativesстатья
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Дата последнего поиска статьи во внешних источниках: 20 сентября 2013 г.
Аннотация:Convenient preparative methods have been developed for the reduction of the active substance of the medicinal preparation Dimebon (2,8-dimethyl-5-[2-(6-methylpyrid-3-yl)ethyl]-1,2,3,4-tetrahydro-γ-carboline) to the corresponding racemic cis- and trans-1,2,3,4,4a,9b-hexahydro derivatives, distinguished by a high degree of stereoselectivity. The structures of the obtained diastereomeric hexahydro-γ-carbolines were confirmed by various physicochemical methods, including X-ray structural analysis.