Inhibition of inward rectifier potassium currents by chloroquine causes significant electrophysiological changes in the rat thoracic veins myocardiumстатья

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[1] Ivanova A. D., Kuzmin V. S. Inhibition of inward rectifier potassium currents by chloroquine causes significant electrophysiological changes in the rat thoracic veins myocardium // Ученые записки Казанского университета. Серия Естественные науки. — 2018. — Vol. 160, no. 4. — P. 1–11. The thoracic (caval and pulmonary) veins myocardial tissue is considered as a source of ectopic activity capable of initiating atrial fibrillation. The cause of arrhythmogenicity of thoracic veins may be related to the level of inward rectifier potassium current (IK1) in this tissue. Resting and action potentials (RMP and AP) were recorded in the superior caval and pulmonary veins and left atria preparations under basal conditions and under the application of IK1 selective inhibitor chloroquine (5 μM). There were no differences in RMP level, but AP duration in the thoracic veins was significantly longer than in the left atrium under basal conditions. The chloroquine application caused a significantly greater increase in AP duration in the thoracic veins myocardium in comparison with the left atrium. Thus, at the electrophysiological level the thoracic veins myocardium has a lower density of IK1 current.

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