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Association of GA genotype of SNP rs4680 in COMT gene with psoriasisстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 августа 2021 г.
- Авторы: Vladimir Sobolev, Luiza Sakaniya, Artemii Tretiakov, Zarema Kokaeva, Elena Naumova, Olga Rudko, Anna Soboleva, Ivan Danilin, Irina Korsunskaya, Eugene Klimov
- Журнал: Archives of Dermatological Research
- Том: 311
- Номер: 4
- Год издания: 2019
- Издательство: Springer Verlag
- Местоположение издательства: Germany
- Первая страница: 309
- Последняя страница: 315
- DOI: 10.1007/s00403-019-01904-1
- Аннотация: Psoriasis is a multigene and multifactorial skin disease with heterogeneous genetic inheritance. Mental disorders participate in the development of psoriasis as predisposing factors; a correlation of dermatological diseases with pathological anxiety and stress was shown. Meanwhile, there are no studies describing molecular mechanisms of the linkages between psycho-emotional disorders and skin diseases. The aim of this study is to find the associations between SNP in genes COMT (rs4680), DBH (rs141116007), CCKAR (rs1800857) and CCKBR (rs1805002), and psoriasis. Patients were selected according to the 10th revision of International Classification of Diseases (L-40). The sample size was 88 patients. The size of the control sample (population control) was 365 people. Genotyping was performed using PCR-RFLP and real-time PCR. Statistical analysis was performed using WinPepi software. Identification of complex genotypes was performed by the Monte Carlo method using APSampler 3.6.1 algorithm. Among the studied genes, only GA genotype of COMT gene is significantly associated with psoriasis [χ2 = 19.163 (p = 1.3E−5), F (p) = 1.2E−5, OR 3.47 (CI 99% = 1.61–7.91)]. At the moment, the functional significance of this phenomenon is difficult to explain.
- Добавил в систему: Климов Евгений Александрович