|
ИСТИНА |
Войти в систему Регистрация |
Интеллектуальная Система Тематического Исследования НАукометрических данных |
||
Control of fibrinolytic drug injection via real-time ultrasonic monitoring of blood coagulationстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 апреля 2019 г.
- Авторы: Ivlev Dmitry A., Shirinli Shakhla N., Guria Konstantin G., Uzlova Svetlana G., Guria Georgy Th
- Журнал: PLoS ONE
- Том: 14
- Номер: 2
- Год издания: 2019
- Издательство: Public Library of Science
- Местоположение издательства: United States
- Первая страница: 1
- Последняя страница: 17
- DOI: 10.1371/journal.pone.0211646
- Аннотация: In the present study, we investigated the capabilities of a novel ultrasonic approach for real-time control of fibrinolysis under flow conditions. Ultrasonic monitoring was performed in a specially designed experimental in vitro system. Fibrinolytic agents were automatically injected at ultrasonically determined stages of the blood clotting. The following clots dissolution in the system was investigated by means of ultrasonic monitoring. It was shown, that clots resistance to fibrinolysis significantly increases during the first 5 minutes since the formation of primary micro-clots. The efficiency of clot lysis strongly depends on the concentration of the fibrinolytic agent as well as the delay of its injection moment. The ultrasonic method was able to detect the coagulation at early stages, when timely pharmacological intervention can still prevent the formation of macroscopic clots in the experimental system. This result serves as evidence that ultrasonic methods may provide new opportunities for real-time monitoring and the early pharmacological correction of thrombotic complications in clinical practice.
- Добавил в систему: Гурия Георгий Теодорович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | journal.pone.0211646.pdf | 2,1 МБ | 4 марта 2019 [GuriaGeorgy] |