beta-Polymorph of phenazepam: a powder studyстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:The title compound [systematic name: 7-bromo-5-(2-chlorophenyl)- 1H-1,4-benzodiazepin-2(3H)-one] (beta-polymorph), C(15)H(10)BrClN(2)O, has been obtained via cryomodification of the known alpha-polymorph of phenazepam [Karapetyan et al. (1979). Bioorg. Khim. 5, 1684-1690]. In both polymorphs, the molecules, which differ only in the dihedral angles between the aromatic rings [75.4 (2)degrees and 86.2 (3)degrees in the alpha- and beta-polymorphs, respectively], are linked into centrosymmetric dimers via N-H center dot center dot center dot O hydrogen bonds. In the crystal structure of the beta-polymorph, weak intermolecular C-H center dot center dot center dot O hydrogen bonds further link these dimers into layers parallel to bc plane.