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P.3.033 The role of gestational acute stress inthe development of perinatal pathologiesстатья
Информация о цитировании статьи получена из
Web of Science
Дата последнего поиска статьи во внешних источниках: 29 мая 2015 г.
- Авторы: Graf A.V., Maslova M.V., Maklakova A.S., Sokolova N.A., Krushinskaya Ja V., Goncharenko E.N., Bayzhymanov A.A.
- Сборник: 8th ECNP Regional Meeting
- Серия: European Neuropsychopharmacology
- Том: 15
- Год издания: 2005
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 158
- DOI: 10.1016/S0924-977X(05)80329-3
- Аннотация: Pregnant women are considered to be the most vulnerable part of society subjected to stress conditions. The effects of acute stress occurring in the early stages of gestation in the development of pregnancy are of particular interest, for early gestational disturbances may interfere in the normal development of pregnancy or result in perinatal pathology including premature birth and even spontaneous abortion. Premature birth is the major source of perinatal death and disability. Furthermore the intrauterine health of the baby is important for preventing certain adult diseases. The aim of the present study was to evaluate the influence of acute hypoxia (oxidative prenatal stress) on pregnancy and offspring development. White rats were subjected to acute hypobaric hypoxia on the 9-10th day of pregnancy. The morphometric characteristics of newborns were registered from P1 to P60 period. The behavioral activity and the anxiety level were investigated in 60-day-old rat pups using hole board and elevated X-maze tests. The bioamines levels in brain stem and cerebral cortex as well as morphometric analysis of neuronal populations in CA1 and CA4 hippocampal areas were determined using fluorescent and histological methods, respectively. Our studies indicated that low-resistant pregnant rats (the first agonal inspiration was observed less than 5 rain after the beginning of hypoxia) were at increased risk for spontaneous abortion and for having a malformed lower birth weight pups. And their offspring's Kettle index remained significantly lower compared to control for at least P60 period. Besides, prenatal hypoxia elicited many disturbances which were manifested at and after birth. 60-day-old rats of both sexes demonstrated hypoactivity and the decrease of orientative-training reactions whereas young females were also less anxious. Thus acute prenatal stress led to an increased level of emotional and behavioral problems during development and in adult age. Data obtained were in good agreement with observed biochemical and histological changes: the general density of neuronal populations in CA1 and CA4 hippocampal areas was decreased in males and females, surviving antenatal hypoxia. The total number of flee cells in both areas did not change while the number of cells with satellite glia decreased in both sexes. At the same time, the number of morphologically changed cells in CA1 hippocampal area was significantly increased in males but remained unchanged in females. The changes in bioamines levels were also more expressed in males. Thus, NE and DA levels were enhanced in both brain stem and cerebral cortex in males whereas females demonstrated a significant increase of brain stem DA level only. Prenatal maternal stress affects pregnancy outcome and results in early disturbances of brain functions with changes in offspring's behavior.
- Добавил в систему: Граф Анастасия Викторовна