The behavioral and biochemical consequencesof acute perinatal hypoxia in descendants depend upon the period of pregnancyстатья

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[1] The behavioral and biochemical consequencesof acute perinatal hypoxia in descendants depend upon the period of pregnancy / A. V. Graf, M. V. Maslova, A. S. Maklakova et al. // European Neuropsychopharmacology. — Vol. 14 of Supplement 3. — Netherlands: Netherlands, 2004. — P. 395–396. The pt∼rpose of the nlaldy: The pregnant women are considered to be the most vulnerable part of the society subjected to stress conditions. The effects of acute hypoxia happened on the early stages of gestation are of particular interest for early gestational disturbances may interfere in the normal development of pregnancy or result in perinatal pathology including perinatal hypoxicischemic brain damage. The severity of the resulting brain damage is dependent on the intensit:y, duration and time of hypoxia. So the correction methods of antenatal hypoxia consequences are very important. One of the most perspective correction methods is the use of regulatory peptides such as, for example, Semax (ACTH4_r - PGP) known for its antihypoxic and nootropic properties. Method∼: The white rats' females were subjected to acute hypobaric hypoxia on the 4-5 th day of pregnancy (the progestational period) or on the 9-10 th day of pregnancy (beginning of organogenesis). The morphometric characteristics of newborns were registered from the 1 ∼t to the 60 th day of life. Besides, the spontaneous behavioral activity and the anxiety level were investigated in 60-day-old rat pups using the classical behavioral tests while 5-HT-, DA- and NE-levels in brain stem and cerebral cortex were determined using fluorescent methods. ∼.m∼ry of results-" We observed that antenatal stress led to newborn low birth weights and could impact on the developing brain, The changes of bioamines levels depended on time of hypoxia, The effects of acute hypoxia happened in the progestational period were leas eapre∼sed than effects of stress happened on the 9-10 th day of pregnancy, Thus 60-days old males but not females survived perinatal hypoxia in the progestational period demonstrated the increased 5-HT level in brain stem while the other bioamines levels were unchanged, Also the anxiei:y level was enhanced in males while decreased in females, 60-day old males from rats subjected to acute hypoxia on the 9-10 tu day of pregnancy showed the increased levels of NE and DA in brain stem and cerebral cortex, while females of this group demonstrated the increase of 5-HT level in brain stem and DA level either in brain stem or cerebral cortex, 1;asides, 60-day-old rats of both sexes demonstrated hypoactivity and the decrease of rearing whereas young ferrales were also less anxious, The intranasal administration of Semax, 0,01 mg/kg to 60-day-old rat pups eliminated mentioned above hypoxia-induced influences on bioamines balance and diminished the antenatal hypoxia induced behavioral disorganization, Concision: The perinatal hypoxia seems to contribute to the development of severe neurological disturbances especially expressed in 60-day-old males and depended on time of the hypoxia, In some cases hypoxia induced influences can be eliminated by intranasal administration of Semax. [ DOI ]

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