Antenatal hypoxia influence on the development of CNSстатья

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Дата последнего поиска статьи во внешних источниках: 29 мая 2015 г.

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[1] Antenatal hypoxia influence on the development of cns / A. V. Graf, M. V. Maslova, A. S. Maklakova et al. // European Neuropsychopharmacology. — Vol. 14 of Supplement 1. — Netherlands: Netherlands, 2004. — P. 33–34. Perinatal hypoxic-ischemic brain damage is a major cause of acute mortality and chronic neurologic morbidity in infants and children. The severity of the resulting brain damage is dependent on the intensity, duration and time of the hypoxia. Obstetric complications such as prolonged hypoxia is suspected to increase the risk for such mental disorders as schizophrenia, epilepsy, deficit hyperactivity disorder, mental retardation. Animal studies are quite important in providing mechanisms underlying perinatal hypoxia brain damages. One of the most perspective correction method is the use of regulatory peptides, for example Semax (ACTH4-7 – PGP), the well known antihypoxic and nootropic drug. The white rat females were subjected to acute hypobaric hypoxia on the 9–10th day of pregnancy that corresponding to the period of main organism’s systems formation including the nervous one. The morphometric characteristics of newborns were registered from the 1st to the 60th day of life. Besides, the spontaneous behavioral activity and the anxiety level were investigated in 60-day-old rat pups using hole board and elevated X-maze tests while the bioamines levels in brain stem and cerebral cortex as well as morphometric analysis of neuronal populations in CA1 and CA4 hyppocampal areas were determined using fluorescent and hystological methods, respectively. The descendants from females, subjected to acute hypoxia, were born with low birth weight which remained significantly lower compared to control for at least 60 days of their postnatal period. Besides, 60-day-old rats of both sexes demonstrated hypoactivity and the decrease of orientative-training reactions whereas young females were also less anxious. Thus, the antenatal hypoxia induced the noticeable behavioral disorganization. The behavioral effects were in good agreement with observed biochemical and hystological changes. Thus, the general density of neuronal populations in CA1 and CA4 hyppocampal areas was decreased either in males (9,7% and 16,7%, respectively) or in females (9,1% and 11%, respectively), surviving antenatal hypoxia. The total number of free cells in both areas didn’t change while the number of cells with satellite glia decreased by 29,6% in males and 12,6% in females. At the same time, the number of morphologically changed cells in CA1 hyppocampal area was significantly increased in males remained unchanged in females. The changes in bioamines levels were also more expressed in males. Thus, NE and DA levels were enhanced both in brain stem and cerebral cortex in males whereas females demonstrated the significant increase of brain stem DA level only. The intranasal administration of Semax, 0.01 mg/kg to 60-day-old rat pups eliminated mentioned above hypoxia influences on bioamines balance and diminished the antenatal hypoxia induced behavioral disorganization. The antenatal hypoxia seems to contribute to the development of severe neurological disturbances, especially expressed in 60-day-old male rats. In some cases hypoxia induced influences can be eliminated by intranasal administration of Semax. [ DOI ]

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