PRODUCTION AND APPRECIATION OF MONOCLONAL-ANTIBODIES AGAINST SEAL ALKALINE-PHOSPHATASEстатья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 29 мая 2015 г.
Местоположение издательства:Road Town, United Kingdom
Первая страница:1344
Последняя страница:1349
Аннотация:Monoclonal antibodies against seal alkaline phosphatase belonging to the IgG1* subclass and not affecting its enzymatic activity were produced The dissociation constant of the complex of antibodies with phosphatase was equal to 8.5 . 10(-10) M. The antibodies also interact with the intestinal enzyme of common seal, fur seal, calf, and deer alk,aline phosphatases. A complex of antibodies with seal phosphatase was produced and used successfully in enzyme immunoassay (ELISA). The use of this complex made it possible to lower the limit of detectability of antibodies against peptide fragments of HIV-1 and HIV-2 proteins and to detect cytokeratin-8 and vimentin on sections of human kidney and in embryonic fibroblastoid cells, respectively.