Realization of 19F MRI oximetry method using perfluorodecalin

Gulyaev, M.V.; Kuznetsova, A.V.; Silachev, D.N.; Danilina, T.I.; Gervits, L.L.; Pirogov, Y.A.

Авторы: Gulyaev Mikhail V., Kuznetsova Aleksandra V., Silachev Denis N., Danilina Tatyana I., Gervits Lev L., Pirogov Yury A.
Журнал: Magnetic Resonance Materials in Physics, Biology, and Medicine
Том: 32
Номер: 3
Год издания: 2019
Издательство: Springer Verlag
Местоположение издательства: Germany
Первая страница: 307
Последняя страница: 315
DOI: 10.1007/s10334-019-00739-1
Аннотация: ObjectiveTo identify the technical aspects of the potential use of clinically approved perfluorodecalin (PFD, C10F18) for 19F magnetic resonance imaging (MRI) oximetry method at high magnetic field 7.05 T.Materials and methods19F T1 measurements were made on a set of PFD samples with different oxygen contents (0%, 21%, and 100%) at room (21 °C) and body temperature (37 °C). In vivo MRI studies were carried out on one healthy rat and two rats with C6 brain glioma.ResultsThe selective excitation of the magnetically equivalent 19F nuclei of CF2 groups of trans-isomer of PFD, which give a doublet at a frequency of about − 140 ppm (in relation the chemical shift of trifluoroacetic acid, which is − 76.55 ppm) should be done for correct implementation of 19F MRI oximetry method. The amount of PFD equal to 30 μl is the optimal for obtaining reliable data on the measured T1 values. In this case, the standard deviation of T1 does not exceed 5%. In vivo MRI studies showed that the values of the partial pressure of oxygen (pO2) decrease from normal values of about 38 mmHg (healthy brain) to almost 0 mmHg at the last stage of tumor growth.ConclusionThe study showed the feasibility of the successful application of PFD for 19F MRI oximetry method.
Добавил в систему: Гуляев Михаил Владимирович

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№	Имя	Описание	Имя файла	Размер	Добавлен
1.	razreshenie_oksimetriya.pdf		razreshenie_oksimetriya.pdf	141,5 КБ	9 апреля 2021 [GervitsL.L.]
2.	Полный текст		oksimetriya_MAGMA_2019.pdf	1,1 МБ	20 апреля 2021 [GervitsL.L.]

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Интеллектуальная Система Тематического Исследования НАукометрических данных

Realization of 19F MRI oximetry method using perfluorodecalinстатья

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