Bioaktive peptide complex from bovine lactoferrin

Авторы: Samokhina L.S., Ionova I.I., Komolova G.S.
Журнал: Problems of Biological, Medical and Pharmaceutical Chemistry
Том: 12
Номер: 9
Год издания: 2014
Первая страница: 39
Последняя страница: 42
Аннотация: Bioaktive peptide complex marked as IV LF was isolated from bovine lactoferrin by pepsin hydrolysis. Mass spectrometric researches showed, that the complex consists of 7 peptides with molecular weight less than 3 kDa.Their length doesnt exceed 18 amino acid residues.Pepsin hydrolysate of the lactoferrin obtained from bovine milk possesses antimicrobial, bifidogenic,antioxidant,anti-ulcer qualities,which are more effective than in native lactoferrin. We identified peptide with high level of redox-active amino acid residues (Tyr, Trp, Met, Cys, His),than determine lactoferrin and its hydrolysates antioxidant activity. Amino acid sequences analysis comparing to lactoferrin proteolysis Insilico modeling with Peptide Cutter program indicates that IV LF complex peptides can be predicted in most cases. The question of possible ways of increasing lactoferrin functional domens bioactivity while proteolysis is discussing. There is a reason of considering perspective of using IV LF peptide complex as an active base of medical and preventative measures in virtue of received data.
Добавил в систему: Самохина Людмила Сергеевна

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