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A comparative study of the reactions of thermally activated tritium with sugars and diazines and of solid-phase catalytic hydrogenation of these compounds with tritiumстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.
- Авторы: Sidorov G.V., Badun G.A., Baitova E.A., Baitov A.A., Platoshina A.M., Myasoedov N.F., Fedoseev V.M.
- Журнал: Radiochemistry
- Том: 47
- Номер: 3
- Год издания: 2005
- Издательство: Pleiades Publishing, Inc.
- Местоположение издательства: New York, USA
- Первая страница: 311
- Последняя страница: 315
- DOI: 10.1007/s11137-005-0095-5
- Аннотация: The feasibility of the labeling procedure involving thermal activation (TA) of tritium was examined with the substrates that are commonly labeled by solid-phase catalytic hydrogenation (SCH) with tritium. Comparative characteristics of SCH and TA as procedures for tritium labeling of sugars and diazines were obtained. These two methods ensure comparable rates of tritium incorporation into purine and pyrimidine bases. The SCH allows preparation of tritium-labeled compounds with the maximum possible molar radioactivity. The molar radioactivity of the same compounds labeled using TA did not exceed 37 TBq mol -1, because only a small fraction of the substrate could react with atomic tritium. Longer reaction times and increased amounts of tritium taken into the reaction resulted in stronger degradation of the substrates. On the assumption that the reactive tritium atoms penetrate into the target to a depth of 0.5 nm, the actual specific radioactivity of the labeled compound in the zone accessible for atomic tritium reaches 0.2-2 PBq mol -1. Ways are suggested to increase the molar radioactivity of compounds labeled using thermal activation of tritium. ©2005 Pleiades Publishing, Inc.
- Добавил в систему: Бадун Геннадий Александрович