Synthesis, characterization, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulphur-containing terpyridinesстатья

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Дата последнего поиска статьи во внешних источниках: 28 июня 2016 г.

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[1] Synthesis, characterization, cytotoxicity and antibacterial activity of ruthenium(ii) and rhodium(iii) complexes with sulphur-containing terpyridines / E. K. Beloglazkina, E. A. Manzheliy, A. A. Moiseeva et al. // Polyhedron. — 2016. — Vol. 107. — P. 27–37. The synthesis and characterization of novel thioacetyl-functionalised terpyridine ligands and their ruthenium and rhodium complexes [Ru(tpy)2](PF6)2, [Rh(tpy)2](PF6)3, [Ru(phen)(tpy)Cl](PF6), [Rh(phen)(tpy)Cl](PF6)2 (phen = phenanthroline; tpy = S-[ω-(2,2:6’,2’’-terpyridin-4’-yl)phenoxy]alkyl ethanethioate) have been described. Ligands and complexes were characterized by 1H NMR spectroscopy, mass spectrometry, elemental analysis and cyclic voltammetry data. The crystal structure of the complex [Rh(phen)(tpy)Cl](PF6)2 (phen = phenanthroline; tpy = 4’-phenyl-2,2’:6’,2’’–terpyridine) (21), have been determined by X-ray crystallography. Complex 21 show a distorted octahedral geometry around the ruthenium centre. Antimicrobial activity toward E. coli at concentrations as low as 5 μM was found for some of the studied complexes. For complexes [Rh(tpy-C6H4-O(CH2)8-SCOCH3)2](PF6)3 (19), [Rh(phen)(tpy-C6H4-O-(CH2)8-SCOCH3)Cl](PF6)2 (31) and [Rh(phen)(tpy-C6H4-O-(CH2)11-SCOCH3)Cl](PF6)2 (32), a strong inhibition of in vitro protein synthesis was observed using firefly luciferase. An investigation of cytotoxicity of the complexes against human embryonic kidney cells (HEK293 line) by the MTT assay demonstrates that the toxicity of all tested compounds is of similar magnitude, with IC50 values of 3 to 30 μM. [ DOI ]

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