A molecular dynamic study of layered hydroxide induced depletion of mobile anions within the extracellular medium

Авторы: Tsukanov A.A., Psakhie S.G.
Сборник: Advanced Materials with Hierarchical Structure for New Technologies and Reliable Structures
Том: 1683
Год издания: 2015
Место издания: AIP Publishing Tomsk, Russia
Первая страница: 020232
Последняя страница: 020232
DOI: 10.1063/1.4932922
Аннотация: The strong surface electric charge density of clay mineral host nanolayers enables their use as host-guest nanohybrids in many different areas of application. In particular layered double hydroxides (LDH) of metals have found applications in medicine. Drug-LDH or gene-LDH nanohybrids are used for targeted delivery of biomedical agents to diseased cells or cancer cells. Fragments of the LDH host nanolayers may remain both within the cell and in the extracellular medium after drug delivery. How these charged nanosheets affect the cell electrostatics is still poorly understood. In the present paper the idealized case of a single pure Mg2/Al-LDH nanolayer interacting with the extracellular anion environment was investigated to estimate the order of magnitude of a possible shift of the cell membrane equilibrium potential. An approximate dependence of the change in the chloride equilibrium membrane potential on the concentration of pure Mg2/Al-LDH nanosheets was determined.
Добавил в систему: Цуканов Алексей Алексеевич

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