Water-soluble polyplexes of modified chitosanстатья
Информация о цитировании статьи получена из
Web of Science ,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Авторы:
Kostina N.Yu a ,
Gorshkova M.Yu a ,
Izumrudov V.A.b
Журнал:
Polymer Science, Series A
Том:
53
Номер:
10
Год издания:
2011
Издательство:
Pleiades Publishing, Ltd
Местоположение издательства:
Road Town, United Kingdom
Первая страница:
947
Последняя страница:
954
DOI:
10.1134/S0965545X11090045
Аннотация:
The alkylation of primary amino groups of chitosan with glycidyltrimethylammonium chloride yields the modified cationic polysaccharide that carries, in practically every deacetylated unit, a secondary amino group and a quaternized amino group that provide the solubility of the polymer over the whole range of pH values. The mixing of solutions of modified chitosan and nucleic acid in neutral solutions at various ratios gives soluble DNA-containing polyelectrolyte complexes (polyplexes) that preserve stability under physiological conditions. The effects of the pH, ionic strength, and charge-to-charge ratio of polymer components on the boundaries of existence of soluble polyplexes both negatively and positively charged are elucidated. The collected experimental data may serve as a basis for designing biocompatible and biodegradable means for the delivery of genetic material and drugs to living cells. © 2011 Pleiades Publishing, Ltd.
Добавил в систему:
Изумрудов Владимир Алексеевич