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Selenium and Male Reproductionстатья
- Авторы: Turanov Anton A., Malinouski Mikalai, Gladyshev Vadim N.
- Сборник: Selenium
- Место издания: Springer US Boston, MA
- Первая страница: 409
- Последняя страница: 417
- DOI: 10.1007/978-1-4614-1025-6_32
- Аннотация: Selenium (Se) has long been known to be important for male reproduction as severe Se deficiency causes impaired male fertility in livestock, laboratory animals, and humans. In the last decade, the role of Se in male reproduction was elucidated at the molecular level, establishing the roles of specific selenoproteins in this process. Using protein- and isoform-specific knockout mice, it was found that at least two selenoproteins are responsible for the effect of Se: Selenoprotein P, a protein secreted from the liver and serving as the main source of Se for testes, and a mitochondrial form of glutathione peroxidase 4 that has two functions: a peroxidase specific for phospholipid hydroperoxides and a structural component in the midpiece of sperm. Clinical studies further showed that the compromised glutathione peroxidase 4 function in testes is associated with male infertility. In addition, application of X-ray fluorescent microscopy allowed direct visualization of Se distribution in testis and sperm, defining the roles of individual selenoproteins during spermatogenesis. Finally, recent identification of individuals with SBP2 mutations characterized by impaired fertility and azoospermia provided further evidence for importance of Se and selenoproteins in male reproduction.
- Добавил в систему: Гладышев Вадим Николаевич