Methylcellulose films partially crosslinked by iron compounds for medical applicationsстатья

Информация о цитировании статьи получена из Scopus, Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 21 февраля 2019 г.

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[1] Methylcellulose films partially crosslinked by iron compounds for medical applications / I. V. Fadeeva, E. S. Trofimchuk, S. K. Dedushenko et al. // Materials Today Communications. — 2019. — Vol. 18. — P. 54–59. Methylcellulose (MC) is now widely used in medicine to fill defects of damaged tissues. A new method is proposed to improve the stability of MC-based materials in aqueous media using non-toxic reagents. MC–alginate blend films are crosslinked by iron(II) and iron(III) ions using different iron salts. The resulting films are stable in physiological solution for about 14 days. Mechanical tests of the dried films show an increase in the Young's modulus with iron concentration in solutions. Mössbauer spectroscopy data show that the films contain Fe3+ ions alone irrespective of whether chlorides of Fe2+ or Fe3+ are applied as crosslinking agents. The use of ascorbic acid as a complexing agent prevents Fe2+ from oxidation. The obtained materials are stable for at least half a year. The resulting films facilitate the growth of human fibroblasts on their surface. [ DOI ]

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