The cyanotoxin BMAA induces heterocyst specific gene expression in Anabaena sp. PCC 7120 under repressive conditionsстатья

Статья опубликована в высокорейтинговом журнале

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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 16 декабря 2018 г.

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[1] The cyanotoxin bmaa induces heterocyst specific gene expression in anabaena sp. pcc 7120 under repressive conditions / A. Popova, T. Semashko, N. Kostina et al. // Toxins. — 2018. — Vol. 10, no. 11. — P. 478. Cyanobacteria synthesize neurotoxic non-protein amino acid s-N-methylamino-L-alanine (BMAA). The functions of this cyanotoxin in cyanobacterial cells are insufficiently studied. In nitrogen-free growth medium filamentous cyanobacteria form single specialized cells, heterocysts, which are separated by approximately twelve-fifteen vegetative cells. When combined nitrogen is available formation of heterocysts is blocked and cyanobacterial filaments contain only vegetative cells. In the present study, we discovered that exogenous BMAA induced the processes leading to heterocyst formation in filamentous cyanobacteria under repressive conditions. BMAA treated cyanobacteria form heterocyst-like dark non-fluorescent non-functional cells in the nitrogen containing growth medium. This BMAA mediated derepression is eliminated by glutamate. The RT-qPCR was applied to check the effect of exogenous BMAA on the transcriptional activity of several key genes implicated in nitrogen assimilation and heterocyst formation under nitrogen-replete conditions in Anabaena sp. PCC 7120. It was found that expression of several essential genes of nitrogen metabolism and heterocyst formation increased in the presence of BMAA under repressive conditions. [ DOI ]

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