New functionalized hydroxymethylphosphonates including moieties of piperidine and its polycyclic analogs with prospective multifactor activityтезисы доклада Тезисы

Дата последнего поиска статьи во внешних источниках: 11 апреля 2019 г.

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[1] New functionalized hydroxymethylphosphonates including moieties of piperidine and its polycyclic analogs with prospective multifactor activity / A. A. Prishchenko, R. S. Alekseyev, M. V. Livantsov et al. // THE RUSSIAN CLUSTER OF CONFERENCES ON INORGANIC CHEMISTRY “INORGCHEM 2018”. Abstracts reports. — 1st Russian Conference on Bioinorganic Chemistry (RuBIC) with International Participation. — Издательство АГТУ Россия, Астрахань, 2018. — P. P–14. Functionalized hydroxymethylphosphonates and phosphorus-containing amino acids are widely used as polydentate ligands and biologically active substances with various properties. Thus, these compounds with hydrolytically stable P-C bonds are widely used as effective herbicides and the structural core of new types of antibiotics.[1] Phosphorus-containing cyclic analogs of 4-aminobutyric acid with piperidine fragments are of particular interest due to their antitumor properties and their activity as effective neuromodulators. The diverse biological activity of the polycyclic piperidine analogs, including fragments of quinuclidine, nitrogen-containing adamantane derivatives, adamantane carboxylic acids and bornan (camphane), which are widely used in pharmaceutical synthesis, are also well known.

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