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The calcium-independent receptor of alpha-latrotoxin is not a neurexinстатья
Информация о цитировании статьи получена из
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Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 октября 2018 г.
- Авторы: Krasnoperov, (Krasnoperov VG, VG); Beavis, (Beavis R., R); Chepurny, (Chepurny OG, OG); Little, (Little AR, AR); Plotnikov, (Plotnikov AN, AN); Petrenko, (Petrenko AG, AG)
- Журнал: Biochemical and Biophysical Research Communications
- Том: 227
- Номер: 3
- Год издания: 1996
- Издательство: Academic Press
- Местоположение издательства: United States
- Первая страница: 868
- Последняя страница: 875
- DOI: 10.1006/bbrc.1996.1598
- Аннотация: alpha-Latrotoxin (alpha-LTx), a vertebrate neurotoxin isolated from Black Widow Spider venom, causes massive spontaneous neurotransmitter release. The molecular mechanism(s) by which the toxin exerts its effect is largely unknown. Here we report identification and purification of a novel membrane receptor with high affinity for alpha-LTx. Unlike neurexin Ia, a previously described high affinity alpha-LTx receptor, this novel protein binds alpha-LTx independently of Ca2+ presence and therefore may be a mediator of the calcium-independent stimulation of neurotransmitter release by alpha-latrotoxin. The major protein component of calcium-independent alpha-LTx receptors is a novel Mr 120,000 protein which does not belong to the neurexin family. Among several tissues tested, the Mr 120,000 protein was found only in brain. (C) 1996 Academic Press, Inc.
- Добавил в систему: Петренко Александр Георгиевич