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Association study of polymorphic markers of F12, PON1, PON2, NOS2, PDE4D, HIF1a, GPIba, CYP11B2 genes with ischemic stroke in Russian patientsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Дата последнего поиска статьи во внешних источниках: 4 сентября 2018 г.
- Авторы: Avdonina M.A., Nasedkina T.V., Ikonnikova A.Yu, Bondarenko E.V., Slominsky P.A., Shamalov N.A., Shetova I.M., Limborskaya S.A., Zasedatelev A.S., Skvortsova V.I.
- Журнал: Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
- Том: 112
- Номер: 2
- Год издания: 2012
- Издательство: Media Sphera
- Местоположение издательства: Russian Federation
- Первая страница: 51
- Последняя страница: 54
- Аннотация: Allele and genotype frequencies of 10 single nucleotide polymorphisms in F12, PON1, PON2, NOS2, PDE4D, HIF1a,GPIba, CYP11B2 genes were studied in a group of Russian patients with ischemic stroke (IS) from central regions of the Russian Federation and healthy donors matched for sex, age and ethnicity. The genotyping procedure included the amplification of selected DNA sequences with the following hybridization of fluorescently-labeled regions with allele-specific DNA-probes immobilized on a biochip. An analysis of allele and genotype frequencies for each gene in IS patients and controls did not reveal any significant differences. The pair-wise comparison of genes demonstrated that the frequency of the combination PON1A/-x PON2 GG was higher in the group of patients (p=0.044, OR=3.4 95% CI 1.06-10.4) compared to the controls and, thus, was associated with the higher risk for stroke.
- Добавил в систему: Бондаренко Елена Александровна