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Changes in chromosome positioning may contribute to the development of diseases related to X-chromosome aneuploidyстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Petrova N.V., Yakutenko I.I., Alexeevski A.V., Verbovoy V.A., Razin S.V., Iarovaia O.V.
- Журнал: Journal of Cellular Physiology
- Том: 213
- Номер: 1
- Год издания: 2007
- Издательство: John Wiley & Sons Inc.
- Местоположение издательства: United States
- Первая страница: 278
- Последняя страница: 283
- DOI: 10.1002/jcp.21118
- Аннотация: The radial positions of the centromeric regions of chromosomes 1 and X were determined in normal male fibroblasts (XY) and in fibroblasts from a patient with a rare case of XXXXY polysomy. The centromeric regions and presumably the whole territories of active X chromosomes were demonstrated to occupy similar, although not identical, positions in XY and XXXXY cells. The centromeres of inactive X chromosomes (Barr bodies) were located closer to the nuclear periphery as compared with the centromeres of active X chromosomes. In addition, it was established that the nuclear radial position of gene-rich chromosome 1 was changed in XXXXY cells as compared to normal XY cells. The data are discussed in the context of the hypothesis postulating that changes in nuclear positioning of chromosomal territories induced by the presence of extra copies of individual chromosomes may contribute to the development of diseases related to different polysomies.
- Добавил в систему: Разин Сергей Владимирович