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Early replication timing of the chicken alpha-globin gene domain correlates with its open chromatin state in cells of different lineagesстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Klochkov D.B., Gavrilov A.A., Vassetzky Y.S., Razin S.V.
- Журнал: Genomics
- Том: 93
- Номер: 5
- Год издания: 2009
- Издательство: Academic Press
- Местоположение издательства: United States
- Первая страница: 481
- Последняя страница: 486
- DOI: 10.1016/j.ygeno.2009.01.001
- Аннотация: The vertebrate alpha-globin gene domain is an open chromatin domain overlapping a neighboring house-keeping gene. The tissue-specific cluster of alpha-globin genes and the overlapping housekeeping gene share the same replication origin. We have studied the replication timing of chicken alpha-globin genes in cells of different lineages using the FISH-based approach and found that alpha-globin genes replicate early both in erythroid and in non-erythroid cells, i.e. regardless of their transcriptional activity. Early replication timing of chicken alpha-globin genes in cells of different lineages was in good correlation with the open chromatin configuration of the alpha-globin gene domain in both erythroid and non-erythroid cells. We propose that active transcription of the housekeeping gene overlapping the alpha-globin gene domain enables an access of Origin Recognition Complex (ORC) proteins to the replication origin resulting in early replication of alpha-globin genes even in non-erythroid cells.
- Добавил в систему: Разин Сергей Владимирович