Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6статья
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Дата последнего поиска статьи во внешних источниках: 11 декабря 2015 г.
Аннотация:Recently we reported benzohydroxamic acids (BHAs) as potent and selective inhibitors of hepatitis C virus (HCV) replicon propagation. In this work 12 pyridine hydroxamic acids (PHAs) were synthesized and tested in full-genome replicon assay. It was found that PHAs possessed very similar anti-HCV properties compared to BHAs. Both classes of hydroxamic acids caused hyperacetylation of alpha-tubulin pointing to inhibition of histone deacetylase 6 (HDAC6) as part of their antiviral activity. The tested compounds did not inhibit the growth of poliovirus, displaying high selectivity against HCV. (C) 2015 Elsevier Ltd. All rights reserved.