Selective inhibitor of histone deacetylase 6 (tubastatin A) suppresses proliferation of hepatitis C virus replicon in culture of human hepatocytesстатья

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Дата последнего поиска статьи во внешних источниках: 11 декабря 2015 г.

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[1] Selective inhibitor of histone deacetylase 6 (tubastatin a) suppresses proliferation of hepatitis c virus replicon in culture of human hepatocytes / M. V. Kozlov, A. A. Kleymenova, K. A. Konduktorov et al. // Biochemistry (Moscow). — 2014. — Vol. 79, no. 7. — P. 637–642. Acetylation of alpha-tubulin was studied in cultures of human hepatocytes under the influence of selective inhibitors of histone deacetylases HDAC6 and SIRT-2 - tubastatin A and 2-(3-phenethoxyphenylamino)benzamide, respectively. It was found that in hepatocyte cell line HepG2 acetylated alpha-tubulin is accumulated preferentially on inhibition of HDAC6 but not of SIRT-2. Under the same conditions, no acetylation of alpha-tubulin was observed in hepatocyte cell line Huh7. However, the inhibition of HDAC6 with tubastatin A led to hyperacetylation of alpha-tubulin and simultaneously to decrease in viral RNA concentration in hepatocyte cell line Huh7-luc/neo, which supports propagation of the full genome replicon of hepatitis C virus. The correlation between these two processes points to HDAC6 as a promising cellular target for therapy of hepatitis C. [ DOI ]

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