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Screening of Potential HIV-1 Inhibitors/Replication Blockers Using Secure Lentiviral in Vitro Systemстатья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 апреля 2016 г.
- Авторы: Prokofjeva MM, Spirin PV, Yanvarev DV, Ivanov AV, Novikov MS, Stepanov OA, Gottikh MB, Kochetkov SN, Fehse B., Stocking C., Prassolov VS
- Журнал: Acta Naturae (англоязычная версия)
- Том: 3
- Номер: 4
- Год издания: 2011
- Издательство: Park Media Ltd
- Местоположение издательства: Moscow, Russia (Federation)
- Первая страница: 55
- Последняя страница: 65
- Аннотация: The development and usage of safe cell systems for testing agents which possess anti-HIV activity is a very important factor in the design of new drugs. We have described in detail a system we designed that is based on lentiviral vectors (Prokofjeva et. al., Antiviral Therapy, in print) for swift and completely safe screening of potential HIV-1 replication inhibitors. The system enables one to test the efficiency of the inhibitory activity of compounds whose action is directed towards either wild-type HIV-1 reverse transcriptase or integrase, or mutant enzymes corresponding to the drug-resistant virus form. Testing results of a number of already known drugs, which correlate well with published data as well as data on newly synthesized compounds, were obtained. Application of this system substantially broadens the possibilities of preclinical anti-HIV drugs testing.
- Добавил в систему: Кочетков Сергей Николаевич