Enzymatic activity of thymidine kinases of a herpes simplex virus strains resistant to acyclovir H-phosphonatesстатья
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Дата последнего поиска статьи во внешних источниках: 11 декабря 2015 г.
Аннотация:Some cloned laboratory mutant strains of herpes simplex virus type I resistant to acyclovir H-phosphonate were studied. As was shown for all the clones, the mutations augmented the susceptibility to cidIfovir. Thymidine kinase of the mutant viruses partially retained the capacity to phosphorylate thymidine, but lost the capacity to phosphorylate BVDU.