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Analysis of mutations in DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugsстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 апреля 2016 г.
- Авторы: Korovina A.N., Gus'kova A.A., Skoblov M.Iu, Andronova V.L., Galegov G.A., Kochetkov S.N., Kukhanova M.K., Skoblov Iu S.
- Журнал: Molekuliarnaia biologiia
- Том: 44
- Номер: 3
- Год издания: 2010
- Издательство: Russian Academy of Sciences
- Местоположение издательства: Russian Federation
- Первая страница: 488
- Последняя страница: 496
- Аннотация: The primary structures of DNA-polymerase (ul30) and thymidine kinase (ul23) genes from several herpes simplex virus type 1 (HSV-1) clinical isolates which differed in sensitivity for a number of antiherpetic drugs were determined and compared with those for two laboratory HSV-1 strains one of which was ACV-sensitive (L2), while the another was resistant (L2) to ACV. The phylogenetic analysis of the sequences showed that conserved regions of ul30 gene of HSV-1 clinical isolates and L2 strain were homologous with the exception of point mutations and degenerated substitutions. Several new mutations in the HSV-1 DNA-polymerase and thymidine kinase functional domains were established and identified as the substitutions associated with the strain-resistance to ACV and other drugs
- Добавил в систему: Кочетков Сергей Николаевич