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Fetal valproate syndrome as an experimental model of autismстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 февраля 2019 г.
- Авторы: Malyshev A.V., Abbasova K.R., Averina O.A., Solovieva L.N., Gedzun V.R., Gulyaev M.V., Dubynin V.A.
- Журнал: Moscow University Biological Sciences Bulletin
- Том: 70
- Номер: 3
- Год издания: 2015
- Издательство: Allerton Press
- Местоположение издательства: New York, N.Y., United States
- Первая страница: 110
- Последняя страница: 114
- DOI: 10.3103/S0096392515030074
- Аннотация: High doses of valproic acid (VPA) can modify the activity of many genes by blocking histone deacetylases. Prenatal administration of VPA results in the development of fetal valproate syndrome in the offspring of laboratory animals. This syndrome is considered as a model of autism spectrum disorders. In this review, we discuss the characteristics of the brain state and activity during fetal valproate syndrome at different levels: from the molecular and cellular processes to the behavior. The characteristics of social interaction—the most relevant manifestations of autistic disorders—receive special attention. We present literature data and our own results.
- Добавил в систему: Дубынин Вячеслав Альбертович
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| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Eksperimentalnaya_model_austicheskogo_rasstrojstva_-_indu... | 117,6 КБ | 17 сентября 2018 [akenul] |
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| [1] | Fetal valproate syndrome as an experimental model of autism / A. V. Malyshev, K. R. Abbasova, O. A. Averina et al. // Moscow University Biological Sciences Bulletin. — 2015. — Vol. 70, no. 3. — P. 110–114. High doses of valproic acid (VPA) can modify the activity of many genes by blocking histone deacetylases. Prenatal administration of VPA results in the development of fetal valproate syndrome in the offspring of laboratory animals. This syndrome is considered as a model of autism spectrum disorders. In this review, we discuss the characteristics of the brain state and activity during fetal valproate syndrome at different levels: from the molecular and cellular processes to the behavior. The characteristics of social interaction—the most relevant manifestations of autistic disorders—receive special attention. We present literature data and our own results. [ DOI ] |