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Regulation of murine myocardial energy metabolism during adrenergic stress studied by in vivo 31P NMR spectroscopyстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 16 января 2019 г.
- Авторы: Naumova A.V., Weiss R.G., Chacko V.P.
- Журнал: American Journal of Physiology - Heart and Circulatory Physiology
- Том: 285
- Номер: 5
- Год издания: 2003
- Издательство: American Physiological Society
- Местоположение издательства: United States
- Первая страница: H1976
- Последняя страница: H1979
- DOI: 10.1152/ajpheart.00474.2003
- Аннотация: Image-guided, spatially localized 31P magnetic resonance spectroscopy (MRS) was used to study in vivo murine cardiac metabolism under resting and dobutamine-induced stress conditions. Intravenous dobutamine infusion (24 mug. min-1. kg body wt-1) increased the mean heart rate by approximately 39% from 482 +/- 46 per min at baseline to 669 +/- 77 per min in adult mice. The myocardial phosphocreatine (PCr)-to-ATP (PCr/ATP) ratio remained unchanged at 2.1 +/- 0.5 during dobutamine stress, compared with baseline conditions. Therefore, we conclude that a significant increase in heart rate does not result in a decline in the in vivo murine cardiac PCr/ATP ratio. These observations in very small mammals, viz., mice, at extremely high heart rates are consistent with studies in large animals demonstrating that global levels of high-energy phosphate metabolites do not regulate in vivo myocardial metabolism during physiologically relevant increases in cardiac work.
- Добавил в систему: Наумова Анна Владимировна