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Spectra of Secondary Particles Generated Upon Virtual Irradiation of Gold Nanosensitizers: Implications for Surface Modificationстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 ноября 2018 г.
- Авторы: Belousov Alexandr V., Morozov Vladimir, Krusanov Grigorii, Kolyvanova Maria, Chernyaev Alexander, Shtil Alexander
- Журнал: Biomedical Physics & Engineering Express
- Том: 4
- Номер: 4
- Год издания: 2018
- Первая страница: 045023
- DOI: 10.1088/2057-1976/aac73d
- Аннотация: Surface modifications of radiosensitizing gold nanoparticles (GNP), in particular coating with polyethylene glycol (PEG), may greatly improve their physico-chemical, pharmacological and theranostic properties. However, GNP coating material can seriously alter the efficacy of radiosensitization. We performed a Monte-Carlo simulation of 17 nm GNP PEGylation (8.5 nm layer thickness) effects on secondary radiation spectra at different energies of primary photons (from ~8 keV to 1 MeV). Our calculations revealed a decrease of the amount of low energy electrons (LEE) that leave PEGylated GNP (from 20% to 40% at the photon energy <500 keV, and from 20% to 0% at energies 500–1000 keV). In all cases, the average energy of the low-energy component of the electron spectrum was smaller for coated GNP. Total energy differed only slightly at photon energy up to ~200 keV; at bigger energies the normalized total energy of secondary electrons that left the PEG shell significantly (~20%) exceeded the respective value for electrons that left the uncoated GNP. Thus, rational design of GNP-based radiosensitizers should include critical assessment of physico-chemical properties of the material used for surface modification.
- Добавил в систему: Крусанов Григорий Андреевич