Contact activation of blood coagulation: trigger properties and hysteresis. Kinetic recognition of foreign surfaces upon contact activation of blood coagulation: a hypothesisстатья

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Дата последнего поиска статьи во внешних источниках: 2 декабря 2015 г.

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[1] Pokhilko A. V., Ataullakhanov F. I. Contact activation of blood coagulation: trigger properties and hysteresis. kinetic recognition of foreign surfaces upon contact activation of blood coagulation: a hypothesis // Journal of Theoretical Biology. — 1998. — Vol. 191, no. 2. — P. 213–219. A mathematical model of contact activation of blood coagulation was developed and analysed. The model variables are concentrations of factor XIIa, kallikrein and activated high-molecular-weight kininogen. Concentrations of active factors were shown to depend on the activating signal value in a hysteretic manner. Within a range of relatively small signals, two (activated and non-activated) stable states coexist (bistability). Signals of the natural environment (surfaces of endothelial and blood cells) seem to be in the range of bistability; therefore, contact activation that persists for a short time can induce a transition of the system to the activated state, and, correspondingly, the formation of a clot. The system cannot return to the initial state, which is characterized by low activation levels, until the activating signals decrease significantly below those present in the circulation. [ DOI ]

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